P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets.
Wilkins PP, Moore KL, McEver RP, Cummings RD: Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. J Biol Chem. 1995 Sep 29;270(39):22677-80. [PubMed:7559387] Florian V, Schluter T, Bohnensack R: A new member of the sorting nexin family interacts with the C-terminus of P-selectin.
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1 . Inscriptiones Phænicias continens . T . 1 : 1 - 3 ( text & pl .
Selectins interact with specific carbohydrates expressed by activated endothelial cells, monocytes, and neutrophils. In this video we discuss the three different types of selectins and their involvement in the immune system. 2007-07-15 · Ma, Y-Q., Plow, E.F. & Geng, J.-G.
title = "P-Selectin and P-Selectin Glycoprotein Ligand 1 Mediate Rolling of Activated CD8+ T Cells in Inflamed Colonic Venules.",. abstract = "BACKGROUND::
Full text. Free. Antigensymbol, P-Selectin.
P-selectin P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule ( CAM)
Upon injury in a blood vessel, platelets become activated and adbere to prevent blood loss. Activated platelets express adhesion molecules on their surface that also make leukocytes adhere to the i This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor Clq. Mangell, Peter et al. "Critical role of P-selectin-dependent leukocyte recruitment in endotoxin-induced intestinal barrier dysfunction in mice.".
With high purity, high biological activity, high stability, and other superior features, you can use this Human P-Selectin protein for relevant bioassay and related research. Upon injury in a blood vessel, platelets become activated and adbere to prevent blood loss. Activated platelets express adhesion molecules on their surface that also make leukocytes adhere to the i
This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor Clq.
Mangell, Peter et al. "Critical role of P-selectin-dependent leukocyte recruitment in endotoxin-induced intestinal barrier dysfunction in mice.". Inflammation Research. 2007, 56(5). 189-194.
GBT is also advancing its pipeline program in SCD with inclacumab, a p-selectin inhibitor in development to address pain crises associated with the disease. Framför allt har arbetet fokuserats på proteinerna ICAM-1 och P-selectin som spelar en viktig roll för rekrytering av vita blodkroppar från blodet ut i vävnaden.
What does p-selectin mean? Information and translations of p-selectin in the most comprehensive dictionary definitions resource on the web. 2021-03-22 · P-selectin is expressed in trauma-induced coagulopathy with mechanical dysfunction.
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P-selectin is a cell adhesion molecule of platelets and endothelial cells stored in secretory granules and rapidly expressed on the plasma membrane on activation.10-13 After expression on the cell surface both endothelial and platelet P-selectin mediate leukocyte adhesion.14 Whereas endothelial P-selectin has clearly been shown to be involved in leukocyte and platelet rolling,15,16 the role of
Download Citation | P- and E-selectin | P- and E-selectin, commonly referred to as the “endothelial” selectins, were initially described and characterized in the P-selectin is found in secretory granules of platelets (α-granules) and endothelial cells (Weibel-Palade bodies) and upon activation is present on the surface of platelets and endothelial cells. E-selectin expression on activated endothelial cells requires de novo transcription, thus occurs several hours after stimulation and persists for a longer time period as observed in chronic inflammation. P-selectin is a molecule expressed on active blood vessels, such as those found in tumors. To take advantage of this observation, Shamay et al. designed nanoparticles containing fucoidan, a polysaccharide that specifically binds to P-selectin, and demonstrated that these can deliver a variety of chemotherapeutic drugs to tumors.